Mucus-stimulating factor in tears

Discussion. The implantable system described in this report provides a method for delivering aqueous solutions to the external rabbit eye for at least 6 weeks. The PTFE tube is implanted in the superior conjunctival fornix 4 weeks prior to the implantation of the pump. During this time fibrous tissue ingrowth secures the tube firmly to the surrounding tissues. By allowing the tube to be anchored by fibrous tissue ingrowth, problems with extrusion or retraction are largely eliminated. The tube appears to be well tolerated, and the Infusaid pump provides a fluid source which is easily refilled and requires no batteries or external power source. The system provides a convenient, dependable method for delivering drugs to the external eye for at least 6 weeks. This is an advantage over the Alzet minipump, which lasts for approximately 1 week and requires replacement thereafter. The present system can be refilled repeatedly without surgical intervention or manipulation of the ocular tissues. This reduces the risk of inflammation and infection at the pump sites.